Defects in Cholesterol Metabolism, Due to TDP-43 Protein, Tied to ALS

Defects in Cholesterol Metabolism, Due to TDP-43 Protein, Tied to ALS

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Defects in Cholesterol Metabolism, Due to TDP-43 Protein, Tied to ALS

Defects in cholesterol metabolism may account for some of the neurological damage that occurs in amyotrophic lateral sclerosis (ALS) and other diseases marked by problems with the protein TDP-43, a study reported. As cholesterol  is crucial to nerve cells, these results suggest that restoring its metabolism may be a useful treatment approach. The study, “TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination,” was published in the Journal of Cell Biology. Cholesterol is a fatty substance…

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