Prime Editing, Advance on CRISPR, Shows Potential on CFTR Mutations

Prime Editing, Advance on CRISPR, Shows Potential on CFTR Mutations

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Prime Editing, Advance on CRISPR, Shows Potential on CFTR Mutations

Researchers corrected mutations underlying cystic fibrosis (CF) in a three-dimensional (3D) cell model of the disorder, using a new form of gene editing. This work serves as a proof-of-principle for the technique — called prime editing, seen as an improvement on the CRISPR/Cas9 gene editing tool — and raises the possibility of a future cure, according to the scientists. The study, “Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids,” was published in the…

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