TP73 Gene Mutations May Be Risk Factor for Sporadic ALS

TP73 Gene Mutations May Be Risk Factor for Sporadic ALS

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TP73 Gene Mutations May Be Risk Factor for Sporadic ALS

Rare mutations in the TP73 gene, which is involved in the regulation of a cell’s life cycle, may put a person at greater risk of amyotrophic lateral sclerosis (ALS), according to a genetic analysis of nearly 2,900 sporadic ALS patients. Such mutations were found to affect the maturation and survival of motor neurons in zebrafish, in ways similar to those seen in ALS patients. “Our study has identified a new genetic risk factor for sporadic ALS,” Lynn…

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