Loss of C9orf72, ALS-linked Gene, Affects Motor Skills in Early Study 

Loss of C9orf72, ALS-linked Gene, Affects Motor Skills in Early Study 

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Loss of C9orf72, ALS-linked Gene, Affects Motor Skills in Early Study 

Diminished activity in the C9orf72 gene that is linked with amyotrophic lateral sclerosis (ALS) affected the neuromuscular junction — where nerve and muscle cells connect — in a zebrafish model, establishing the model as a disease research tool and the gene’s role in ALS symptoms. Zebrafish in this C9orf72 loss-of-function model showed “motor defects, muscle atrophy, motor neuron loss and mortality in early larval and adult stages,” scientists reported. As such, they expect the model will be of…

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