CFTR Protein Dynamic, Changing Shapes in Ways Affecting Disease

CFTR Protein Dynamic, Changing Shapes in Ways Affecting Disease

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CFTR Protein Dynamic, Changing Shapes in Ways Affecting Disease

Cystic fibrosis transmembrane conductance regulator (CFTR), the protein that is mutated in cystic fibrosis (CF), is not as rigid a structure as previously thought, but rather one that may transition between shapes, a molecular study has found. Under certain conditions — such as the most common CF-causing mutation, F508del — this transition may predispose the protein to fold into an incorrect shape and end up getting degraded. These findings change the current understanding of the…

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