Metabolic Enzyme Shows Potential as IPF Therapy in Early Study

Metabolic Enzyme Shows Potential as IPF Therapy in Early Study

301462

Metabolic Enzyme Shows Potential as IPF Therapy in Early Study

Blocking the activity of a metabolic enzyme called succinate dehydrogenase (SDH) promoted the death of myofibroblasts — the main drivers of pulmonary fibrosis (PF) — and helped to heal persistent lung scarring (fibrosis) in a rat model, a study reported. These benefits were associated with a rescue of the metabolic abnormalities found in the rats’ fibroblasts — cells that mature into myofibroblasts upon tissue injury to promote wound healing, but do so excessively in this disease. Notably,…

You must be logged in to read/download the full post.