Animal Models Can Predict Brineura Doses for CLN2 Patients

Animal Models Can Predict Brineura Doses for CLN2 Patients

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Animal Models Can Predict Brineura Doses for CLN2 Patients

Animal models predicted dosing of the enzyme replacement therapy Brineura (cerliponase alfa) for patients with late infantile Batten disease, also called CLN2 disease, a study showed. Scientists said this approach also may be applied to predict cross-species dosing for other similar medicines. “Overall, the approach described here provides an example of how nonclinical data can be leveraged to streamline clinical development in rare disease,” the researchers wrote. Monkeys were used in the study in part…

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