Targeting Ion Channel Piezo1 in T-cells Eased MS in Mice

Targeting Ion Channel Piezo1 in T-cells Eased MS in Mice

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Targeting Ion Channel Piezo1 in T-cells Eased MS in Mice

Removing an ion channel called Piezo1 from immune T-cells lessened disease severity in a mouse model of multiple sclerosis (MS), a study showed. Notably, these beneficial effects were associated with an expansion of regulatory T-cells (Tregs) — a type of immune cell that typically dampens immune and inflammatory responses — without affecting other key T-cell functions. “We found that Piezo1 selectively restrains Treg cells, limiting their potential to mitigate autoimmune neuroinflammation,” Michael D. Cahalan, PhD, the…

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