Potential PAH Therapy TPN171H Found to Be Safe in Healthy Adults

Potential PAH Therapy TPN171H Found to Be Safe in Healthy Adults

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Potential PAH Therapy TPN171H Found to Be Safe in Healthy Adults

TPN171H, an experimental oral therapy for pulmonary arterial hypertension (PAH), was generally safe and showed a favorable pharmacological profile in healthy volunteers, according to data from a Phase 1 clinical trial. The therapy — previously reported to be a more potent and selective PDE5 suppressor than sildenafil in preclinical studies — remained longer in the body than sildenafil and tadalafil, and showed no signs of some worrisome adverse events that have been associated with these other…

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