Higher CDC2 Protein Levels Increase Cell Proliferation in PAH

Higher CDC2 Protein Levels Increase Cell Proliferation in PAH

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Higher CDC2 Protein Levels Increase Cell Proliferation in PAH

A protein known as cell division cycle protein 2 (CDC2) enhances the proliferation of pulmonary artery smooth muscle cells — those lining the walls of lung arteries — in people with pulmonary arterial hypertension (PAH), a study reported. Additionally, the increased level of CDC2 in these cells was found to be dependent on FOXM1 and PLK1, two inducers of cell growth. Overall, the findings suggest that targeting CDC2 could be therapeutically beneficial for the treatment…

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