Scientists Identify PIAS2 Protein as Driver of Parkinson’s Dementia

Scientists Identify PIAS2 Protein as Driver of Parkinson’s Dementia

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Scientists Identify PIAS2 Protein as Driver of Parkinson’s Dementia

PIAS2, a protein that suppresses the immune interferon (IFN)-beta signaling, is found at higher-than-normal levels in neurons of sporadic Parkinson’s patients, particularly in those with Parkinson’s disease dementia (PDD), a study shows. Overproduction of this protein was sufficient to cause PDD-like motor and cognitive symptoms in mice, while its suppression reversed these deficits. PIAS2’s damaging effects were found to be associated with a blockage of mitophagy, the process of recycling damaged mitochondria (which normally supply…

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