Researchers Probe Targets to Reduce Mucus Production

Researchers Probe Targets to Reduce Mucus Production

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Researchers Probe Targets to Reduce Mucus Production

Yap and Taz — two proteins involved in lung injury responses and regeneration — suppress the maturation of mucus-producing goblet cells and limit mucus levels in the lungs, according to a study of mice. These findings suggest that promoting Yap/Taz’s activity may be a potential therapeutic approach to limit the excessive or abnormal mucus production that characterizes cystic fibrosis (CF) and other lung diseases. “By identifying new regulators of goblet cell production, we offer insight into…

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