Anti-CD20 Antibodies Reduce Myelin Loss in MS Rats

Anti-CD20 Antibodies Reduce Myelin Loss in MS Rats

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Anti-CD20 Antibodies Reduce Myelin Loss in MS Rats

Treatment with anti-CD20 antibodies reduced the loss of myelin and improved the survival of neurons in a rat model of multiple sclerosis (MS), a new study reports. The findings imply that B-cells — the immune cells that are killed by anti-CD20 antibodies — play a central role in the development of MS lesions. The study, “Anti-CD20 treatment effectively attenuates cortical pathology in a rat model of widespread cortical demyelination,” was published in the Journal of Neuroinflammation.…

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