Rett Researcher Discovers Molecular Mechanism of MECP2 Binding

Rett Researcher Discovers Molecular Mechanism of MECP2 Binding

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Rett Researcher Discovers Molecular Mechanism of MECP2 Binding

The molecular mechanism by which the protein MeCP2 recognizes and binds to CA repeats — repetitive short sequences of DNA that are found throughout the genome — has been unraveled in a new study that sheds light on the causes of Rett syndrome. Researchers in France discovered that MeCP2 opens sections where chromatin associates with the nuclear lamina (LAD), which is a dense layer of proteins that lines the inside of the nucleus membrane and…

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