Airway Inflammation Affects pH, Response to CFTR Therapies

Airway Inflammation Affects pH, Response to CFTR Therapies

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Airway Inflammation Affects pH, Response to CFTR Therapies

Inflammation in the airways of people with cystic fibrosis (CF) regulates the pH of the surface liquid and increases the response to approved CFTR modulators, a cell-based study suggested. Airway inflammation may be a key determinant in response to CF medicines, the researchers noted. “To advance personalized CFTR modulation, it may be relevant to study the airway inflammatory milieu and its interactions with approved modulators,” they wrote. The study, “Inflammatory cytokines TNFα and IL-17 enhance…

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