Extracellular Matrix Not Seen as Direct Cause of Cell Aging in IPF

Extracellular Matrix Not Seen as Direct Cause of Cell Aging in IPF

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Extracellular Matrix Not Seen as Direct Cause of Cell Aging in IPF

Alterations in the extracellular matrix — the network of molecules that surrounds and supports cells — and cell aging, a process of called senescence, both contribute to tissue scarring in idiopathic pulmonary fibrosis (IPF), according to a recent study. Yet, matrix changes do not lead to senescence, implying that these processes act independently of each other to promote scarring or fibrosis. The study, “Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM,” was published…

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