LL-37 Suppresses Alpha-synuclein Clumping in Parkinson’s

LL-37 Suppresses Alpha-synuclein Clumping in Parkinson’s

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LL-37 Suppresses Alpha-synuclein Clumping in Parkinson’s

LL-37, a natural antimicrobial molecule present in the brain and gut, selectively binds to harmful clumps of the alpha-synuclein protein — a hallmark of Parkinson’s disease — and prevents their further aggregation and toxic effects in lab-grown nerve cells, a study shows. The discovery of such a strong suppressor of alpha-synuclein clumping in the same tissues where this harmful process takes place in Parkinson’s suggests that “LL-37’s activity might respond to a mechanism developed by…

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