Sharp Reaction to Givlaari Possible in Acute Porphyria Patients: Study

Sharp Reaction to Givlaari Possible in Acute Porphyria Patients: Study

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Sharp Reaction to Givlaari Possible in Acute Porphyria Patients: Study

Givlaari (givosiran) may cause homocysteine, an amino acid, to rise to unhealthy levels in some people with acute intermittent porphyria (AIP), according to a recent case study of two patients. Blood levels of homocysteine should be tested in people with acute porphyrias being considered for this treatment, and checked regularly while they are using Givlaari, its investigators advised. The study, “Severe homocysteinemia in two givosiran-treated porphyria patients: is free heme deficiency the culprit?,” was published in the…

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