Research Sheds Light on Potential Immune Changes in IPAH

Research Sheds Light on Potential Immune Changes in IPAH

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Research Sheds Light on Potential Immune Changes in IPAH

A combination of lung injury and increased activation of B-cells — immune cells responsible for antibody production — was sufficient to promote symptoms of pulmonary hypertension (PH) in mice, a study shows. In addition, increased B-cell activation and higher levels of immune cells known to promote antibody production also were found in people with idiopathic pulmonary arterial hypertension (IPAH). Given that previous studies have suggested the potential involvement of self-reactive antibodies in IPAH, these early findings support…

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