Levels of KP Metabolites in Blood, CSF Unlikely as Disease Biomarkers

Levels of KP Metabolites in Blood, CSF Unlikely as Disease Biomarkers

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Levels of KP Metabolites in Blood, CSF Unlikely as Disease Biomarkers

Metabolites seen as potential biomarkers of Huntington’s disease — called kynurenine pathway metabolites — showed little evidence of Huntington’s-specific activity in a recent study. While researchers could not entirely rule out kynurenine pathway metabolites as possible treatment targets, their results suggest that the disease is not well represented by the levels of these molecules as found in patients’ blood and in the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord. The study, “Kynurenine pathway…

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