FA Mouse Models May Not Fully Mimic Human Disease

FA Mouse Models May Not Fully Mimic Human Disease

295633

FA Mouse Models May Not Fully Mimic Human Disease

Truncated forms of frataxin, the protein that is lost in people with Friedreich’s ataxia (FA), were found predominantly in mouse tissues, contrasting with the dominance of non-truncated frataxin in human tissue, a study found.  The findings have implications for mouse models used to mimic the condition in disease research and therapeutic development, the scientists said.  The study, “Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich’s ataxia,” was published in the journal Nature…

You must be logged in to read/download the full post.