MPZ Deficiency Mutations Linked to Milder Neuropathy in CMT1B

MPZ Deficiency Mutations Linked to Milder Neuropathy in CMT1B

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MPZ Deficiency Mutations Linked to Milder Neuropathy in CMT1B

Mild sensory neuropathy was found in a group of Charcot-Marie-Tooth disease type 1 subtype B (CMT1B) patients with myelin protein zero (MPZ) gene mutations that cause insufficient levels of MPZ protein, a study shows. These results are in line with those observed in a mouse model of MPZ deficiency. The investigators noted that the similarity in symptoms between the animal model and the patient group may enable the clinical testing of potential treatments. “Successful therapeutic approaches…

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