Disease Severity Tied to Two Neuroprostanes

Disease Severity Tied to Two Neuroprostanes

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Disease Severity Tied to Two Neuroprostanes

Elevated levels of two neuroprostanes — markers of oxidative stress, a result of insufficient antioxidant defenses against toxic free radicals — are linked with symptom severity and type of mutations in people with Rett syndrome, a study reports. These findings support the potential of the neuroprostanes as biomarkers to assess disease progression in Rett, scientists said. The study, “Circulating 4-F4t-Neuroprostane and 10-F4t-Neuroprostane Are Related to MECP2 Gene Mutation and Natural History in Rett Syndrome,” was published in…

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