Scientists Shed Light on Workings of Mutant Alpha-synuclein Protein

Scientists Shed Light on Workings of Mutant Alpha-synuclein Protein

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Scientists Shed Light on Workings of Mutant Alpha-synuclein Protein

A mutant form of the alpha-synuclein protein — associated with early onset, severe familial Parkinson’s disease — recruits its normal version to propagate the toxic clumps that lead to neurodegeneration, a study in mice has found. The data, specific for the E46K mutant version of alpha-synuclein, suggest that the toxic features of this mutant form can be passed on to the healthy version, thereby boosting alpha-synuclein-associated nerve cell death. These findings shed light on the…

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