MORC2 Mutation Causes Severe Neuropathy in CMT2Z, Case Report Finds

MORC2 Mutation Causes Severe Neuropathy in CMT2Z, Case Report Finds

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MORC2 Mutation Causes Severe Neuropathy in CMT2Z, Case Report Finds

Three people from two unrelated families were found to have Charcot-Marie-Tooth disease type 2Z (CMT2Z) caused by the same MORC2 mutation, called p.Ala406Val, which was linked to severe neuropathy, a case study reported.  One patient’s condition also worsened following treatment with vinblastine for Hodgkin’s lymphoma, and scientists recommended use of this cancer medicine be carefully monitored in people with CMT. “The identification of two additional, unrelated families with the same p.Ala406Val mutation demonstrates the pathogenic role…

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