Patient-derived ‘Mini-brains’ May Help in Understanding PWS

Patient-derived ‘Mini-brains’ May Help in Understanding PWS

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Patient-derived ‘Mini-brains’ May Help in Understanding PWS

New brain-like organoids, or “mini-brains,” that are specific to key regions and derived from patients could serve as models for studies of the underlying neurological and molecular mechanisms of Prader-Willi syndrome (PWS), researchers reported. Notably, the team created arcuate organoids generated from cells of PWS patients, which captured the arcuate nucleus brain region for a first time and recapitulated certain disease signatures observed in patients. The arcuate nucleus is a subregion of the hypothalamus involved in hunger…

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