STAR Candidates Boost GCase in Cell, Animal Models

STAR Candidates Boost GCase in Cell, Animal Models

294068

STAR Candidates Boost GCase in Cell, Animal Models

Gain Therapeutics‘ investigational compounds were able to lessen motor symptoms in a rat model of GBA1-associated Parkinson’s disease and also decrease the levels of alpha-synuclein accumulation in nerve cells — two hallmarks of the neurodegenerative disease. The two candidates — GT-02287 and GT-02329 — are special compounds called STARs (small-molecule structurally targeted allosteric regulators) that were identified using Gain’s proprietary drug discovery platform. “These data demonstrate that our [STARs] compounds open a new potential approach…

You must be logged in to read/download the full post.