Damaged Mitochondria May Drive Autoimmunity

Damaged Mitochondria May Drive Autoimmunity

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Damaged Mitochondria May Drive Autoimmunity

Abnormalities in how mitochondria are “recycled” by cells could contribute to autoimmune diseases like Sjögren’s syndrome, a new study indicates. The study, “IRGM1 links mitochondrial quality control to autoimmunity,” was published in Nature Immunology. Often referred to as the “powerhouse of the cell,” mitochondria are cellular structures that play critical roles in energy generation, as well as in making various molecules necessary for cellular functions. Within mitochondria, there are nucleic acids — DNA and RNA — that…

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