Transporter Protein May Underlie Sex Differences in Parkinson’s Risk

Transporter Protein May Underlie Sex Differences in Parkinson’s Risk

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Transporter Protein May Underlie Sex Differences in Parkinson’s Risk

Levels of a protein involved in the transport of brain signaling molecules in dopamine-producing neurons appear to be sex specific — higher in female than in male animal models and human cells — and to protect against age-related neurodegeneration, a study reported. Given that older age and male sex are risk factors for Parkinson’s disease, these findings provide insights into the underlying mechanisms of sex-based vulnerability to Parkinson’s, and point to this protein — called vesicular glutamate transporter or VGLUT…

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