Potential PAH Therapy Identified by Cellular Screen of Thousands

Potential PAH Therapy Identified by Cellular Screen of Thousands

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Potential PAH Therapy Identified by Cellular Screen of Thousands

By screening thousands of potential candidates, researchers have identified a compound, called AG1296, that may be useful for the treatment of pulmonary arterial hypertension (PAH). Their findings were published in the journal Science Translational Medicine, in a study, “iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension.” In PAH, the small blood vessels that transport blood in the lungs — the pulmonary arteries — become narrow, resulting in increased blood…

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