Sex, SMN2 Copy Number Influence SMA Type 3 Age of Onset

Sex, SMN2 Copy Number Influence SMA Type 3 Age of Onset

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Sex, SMN2 Copy Number Influence SMA Type 3 Age of Onset

Sex and the number of copies of the “backup” SMN2 gene influence both the age of symptom onset and the risk of losing the ability to walk in people with spinal muscular atrophy (SMA) type 3, according to a Polish registry study. The data also confirmed the notion that earlier symptom onset predicts a more severe disease course, which in this patient population was linked to a higher likelihood of becoming unable to walk. The…

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