Boosting Cell Stress Response May Be Promising Therapy Approach

Boosting Cell Stress Response May Be Promising Therapy Approach

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Boosting Cell Stress Response May Be Promising Therapy Approach

A combination of guanabenz — an approved therapy for high blood pressure — plus riluzole slowed disease progression in adults with early amyotrophic lateral sclerosis (ALS), particularly those with bulbar onset disease, a form of ALS, according to data from a Phase 2 clinical trial. Despite these promising benefits, the highest doses of guanabenz were associated with significantly greater adverse events and drop-out rates, preventing its further clinical development in ALS, the researchers noted. Still, as the…

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