Immune Deficiencies With FVIII Inhibitors Evident, But Can Be Restored

Immune Deficiencies With FVIII Inhibitors Evident, But Can Be Restored

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Immune Deficiencies With FVIII Inhibitors Evident, But Can Be Restored

Hemophilia A patients with factor VIII (FVIII) inhibitors show deficiencies in regulatory B- and T-cells — immune cells that typically dampen immune and inflammatory responses — but their levels can be restored with successful immune tolerance induction (ITI), a study shows. These findings shed light on how ITI — given to eradicate inhibitors in patients — works in the body, and support evidence linking the presence of FVIII inhibitors with a reversible deficiency in peripheral immune…

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