Signaling Defects Affecting Nerve Cell Growth Identified in Fragile X

Signaling Defects Affecting Nerve Cell Growth Identified in Fragile X

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Signaling Defects Affecting Nerve Cell Growth Identified in Fragile X

Abnormal protein production associated with fragile X syndrome was coupled with altered cell growth that favored fast-growing cell types over those that become nerve cells during early development, a study has shown.  Blocking a signaling pathway known as PI3K corrected both excess protein production and altered cell growth, the researchers found. This suggests that specific interventions may correct these imbalances and be an effective strategy to rescue impairments in fragile X. The study, “Cell-type-specific profiling…

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