PDE4 Inhibitors May Help Treat CF, Dry Mouth

PDE4 Inhibitors May Help Treat CF, Dry Mouth

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PDE4 Inhibitors May Help Treat CF, Dry Mouth

Blocking an enzyme called phosphodiesterase-4 (PDE4) may be useful in the treatment of dry mouth and cystic fibrosis (CF), new preclinical research suggests. The study, “Inhibition of cAMP-Phosphodiesterase 4 (PDE4) Induces Salivation in Mice,” is being presented virtually at the American Society for Pharmacology and Experimental Therapeutics annual meeting. PDE4 is an enzyme that helps to modulate the activity of certain signaling molecules within cells. PDE4 is thought to promote inflammation, but the enzyme’s effects are…

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