Mitochondrial DNA Carried in Blood May Trigger Inflammation in Sickle Cell

Mitochondrial DNA Carried in Blood May Trigger Inflammation in Sickle Cell

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Mitochondrial DNA Carried in Blood May Trigger Inflammation in Sickle Cell

People with sickle cell anemia have higher levels of mitochondrial DNA (mtDNA) — DNA specific to mitochondria, the cell’s powerhouses — circulating in the blood than healthy individuals, likely due to the abnormal retention of mitochondria in red blood cells, a study has found. Notably, patients’ mtDNA was found to have significantly fewer chemical modifications relative to healthy people, and to trigger the formation of immune-related traps that promote inflammation. “These study findings suggest that measuring…

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