Technique Reveals Unique Protein Structure of PMP22

Technique Reveals Unique Protein Structure of PMP22

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Technique Reveals Unique Protein Structure of PMP22

Researchers at the University of Michigan and Vanderbilt University have found that mutant PMP22 proteins pair to form a unique, stabilized complex called a dimer. The discovery, which was made using an advanced protein analysis technique, provides new insight into PMP22’s role in Charcot-Marie-Tooth (CMT) disease and may have potential as a therapeutic target.  The study, “Ion Mobility Mass Spectrometry Reveals the Role of Peripheral Myelin Protein Dimers in Peripheral Neuropathy,” was published in the…

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