#AANAM – Neurofilaments Before Spinraza May Predict Motor Improvements

#AANAM – Neurofilaments Before Spinraza May Predict Motor Improvements

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#AANAM – Neurofilaments Before Spinraza May Predict Motor Improvements

Higher blood levels of phosphorylated neurofilament heavy chain (pNF-H) — a marker of nerve cell damage — before beginning Spinraza (nusinersen) treatment are associated with greater motor improvements in children with spinal muscular atrophy (SMA) types 2 or 3. Notably, this association increased over time, reaching statistical significance at about three years of treatment. Those findings come from an analysis of data from the Phase 3 CHERISH clinical trial and the SHINE extension study. The results support…

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