Protein With ‘Switch’ Sensitive to Clumping May Aid in Treating Disease

Protein With ‘Switch’ Sensitive to Clumping May Aid in Treating Disease

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Protein With ‘Switch’ Sensitive to Clumping May Aid in Treating Disease

A chaperone protein called DnaJB8 has an internal molecular “switch” that likely regulates how cells dispose of protein aggregates, like those that cause Huntington’s disease. These findings were detailed in the study “Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone,” published in Nature Communications. Huntington’s is caused by a mutated protein that forms toxic aggregates in cells. Cellular machinery normally helps to clear such abnormal protein clumps, but its workings are complex and not fully understood…

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