Autophagy-targeting Compound Fails to Reduce Heparan Sulfate in Mice

Autophagy-targeting Compound Fails to Reduce Heparan Sulfate in Mice

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Autophagy-targeting Compound Fails to Reduce Heparan Sulfate in Mice

An investigational compound that targets dysfunctional or improperly working autophagy — the removal of unnecessary or damaged cell components — may improve that process and reduce inflammation in a mouse model of Sanfilippo syndrome. However, the compound did not reduce heparan sulfate accumulation or lessen behavioral defects in these mice, according to a project update from the Sanfilippo Children’s Foundation, which had funded a portion of the research. The ongoing research project is being conducted by investigators…

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