Changes to Nerve Cell Membrane May Promote Alpha-synuclein’s Toxic Turn

Changes to Nerve Cell Membrane May Promote Alpha-synuclein’s Toxic Turn

288325

Changes to Nerve Cell Membrane May Promote Alpha-synuclein’s Toxic Turn

Changes in the composition of fat molecules on the membranes of nerve cells appear to change how the alpha-synuclein protein interacts with these same cell membranes, possibly promoting the aggregation that characterizes Parkinson’s disease, new research reports. The study, “The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition,” was published in the journal Nature Communications. Alpha-synuclein is a protein particularly abundant in the brain. When it misfolds and accumulates,…

You must be logged in to read/download the full post.