PDGFA Found to Stimulate Lung Tissue Repair in Aged IPF Mice

PDGFA Found to Stimulate Lung Tissue Repair in Aged IPF Mice

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PDGFA Found to Stimulate Lung Tissue Repair in Aged IPF Mice

Pretreatment with retinoic acid was found to stimulate the repair of damaged alveoli — the tiny air sacs in the lungs — in a mouse model of idiopathic pulmonary fibrosis (IPF) by upregulating a molecule called PDGFA. The researchers used an aged mouse model to simulate the lung injuries found in older IPF patients. Their findings support further development of PDGFA-focused therapeutic strategies that may impact IPF. The study, “Pretreatment of aged mice with retinoic acid…

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