Deleting Mss51 Gene Reduces Fatigue, Increases Endurance in DMD Mice

Deleting Mss51 Gene Reduces Fatigue, Increases Endurance in DMD Mice

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Deleting Mss51 Gene Reduces Fatigue, Increases Endurance in DMD Mice

By deleting the Mss51 gene, scientists were able to reduce fatigue, increase endurance, and ease mitochondrial impairment in a mouse model of Duchenne muscular dystrophy (DMD). Mss51 is a gene that provides instructions to make a skeletal muscle protein specifically found in mitochondria, the small cell compartments responsible for energy production. Despite the benefits shown in these DMD mice, however, the genetic deletion of Mss51 failed to improve the animals’ limb muscle strength — suggesting…

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