A type of protein modification called glycosylation is associated with higher levels of disease-causing antibodies in cold agglutinin disease (CAD), new research suggests. The findings highlight the role that antibody modifications play in antibody-driven diseases like CAD, researchers said. The study, “In from the cold: M‐protein light chain glycosylation is positively associated with cold agglutinin titer levels,” was published in Transfusion. CAD is caused by antibodies called cold agglutinins, which bind to red blood cells…

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