Blocking Glutamine Metabolism May Help Combat OCCC Tumors

Blocking Glutamine Metabolism May Help Combat OCCC Tumors

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Blocking Glutamine Metabolism May Help Combat OCCC Tumors

Ovarian cancer cells harboring mutations in the ARID1A tumor suppressor gene tend to use the amino acid glutamine as a source of energy more often, making the cells more vulnerable to compounds that interfere with glutamine metabolism, scientists found. As proof, they demonstrated that a compound that inactivates glutaminase (the enzyme that normally breaks down glutamine) can prevent tumor growth in mouse models of ovarian clear cell carcinomas (OCCC) whose cancer cells harbor ARID1A mutations.…

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