TDP-43 Protein Abnormalities in ALS Linked to DNA Damage

TDP-43 Protein Abnormalities in ALS Linked to DNA Damage

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TDP-43 Protein Abnormalities in ALS Linked to DNA Damage

Abnormalities in the activity of the protein TDP-43, whose gene is often mutated in amyotrophic lateral sclerosis (ALS), can increase DNA damage in cells, a study shows. These findings shed light on the molecular underpinnings of ALS, and may open new avenues for treatment, its researchers said. The study, “TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage,” was published in PLOS Genetics. The exact biological mechanisms that cause ALS are…

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