Rhythm Pharmaceuticals has identified 31 additional genes whose mutations may be amenable to setmelanotide, its U.S.-approved therapy for genetic obesity disorders linked to the melanocortin-4 receptor (MC4R) pathway. This discovery is the result of Rhythm’s sequencing efforts and precision approach that has been recently validated in a Phase 2 basket study (NCT03013543), leading to the identification of several new MC4R-related disorders with promising responses to setmelanotide. “Leveraging our extensive scientific expertise and years of internal research,…

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