Mouse Study Links Cortical Inflammation to Immune Cell Destruction

Mouse Study Links Cortical Inflammation to Immune Cell Destruction

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Mouse Study Links Cortical Inflammation to Immune Cell Destruction

Multiple sclerosis (MS)-associated inflammation in the cerebral cortex — the outermost layer of the brain that is involved in cognitive function — prompts the destruction of neural connections by specific immune cells, according to a study in a mouse model of MS. These immune cells targeted dendritic spines, which are nerve cell communication structures containing abnormally high levels of calcium — a dysregulation previously associated with nerve fiber degeneration in MS. Importantly, blocking the activation of…

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