Macrophages Stimulate Nerve-associated Scarring in PF, Study Shows

Macrophages Stimulate Nerve-associated Scarring in PF, Study Shows

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Macrophages Stimulate Nerve-associated Scarring in PF, Study Shows

Immune cells called macrophages can stimulate nerve-associated lung scarring (fibrosis) in pulmonary fibrosis (PF), a study reports. Its findings suggest that antagonists (or inhibitors) of alpha-1 adrenergic nerve receptors may be a potential avenue for PF treatment. The study, “Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis,” was published in the Journal of Clinical Investigation. PF is a progressive lung disease characterized by the thickening and stiffening of lung tissue, leading to scarring (fibrosis) that gradually…

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