Based on MRI scans, Huntington’s disease patients with major cognitive impairments have reduced gray matter volume and a thinner brain cortex than those without cognitive problems, a study has demonstrated.  Major cognitive decline was not associated with CAG repeat length, age, or education, suggesting additional mechanisms contribute to cognitive decline in these patients. The study, “Structural brain correlates of dementia in Huntington’s disease,” was published in the journal NeuroImage: Clinical.  A hallmark of Huntington’s disease…

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